Best of luck and safe travels.. when I drove down to Florida from PA, it was me, 2 teenagers, 2 cats, 3 dogs. I made sure I had plenty of water, toilet paper, paper towels, garbage bags, doggy shampoo and bath towels. I also carried a toddler training potty in case we couldn't stop along the way. Lots of snacks, of course.
Advil, tums, something for diarrhea. Flash light. Extra batteries. Motor oil. Extra dog food, baby wipes.
I am sure you'll think of all this... but just in case.. that's the only tip I can think of. Be prepared.
I can always hear my mom saying "It's better to have it and not need it, then to need it and not have it. 😊